If you’ve recently started taking a GLP-1 medication like semaglutide or tirzepatide and noticed a slight nausea, fatigue, or low energy, don’t worry, it’s common.
Your body is simply adjusting to a new rhythm.
GLP-1 medications are potent tools for weight loss and blood-sugar control, but they can also bring temporary side effects as your system adapts. The good news? With the right adjustments to your diet, exercise, and supplement regimen, you can alleviate discomfort and feel more like yourself again.
In this blog, we’ll break down the most common GLP-1 side effects and share simple, science-backed ways to manage them, so you can stay energized, comfortable, and on track with your health goals.
Patients generally tolerate GLP-1 medications well, but some common side effects may occur, especially when starting or increasing the dose:
Serious complications are rare, but let your doctor know if you have severe abdominal pain, vomiting, or other concerning symptoms. For most people, side effects improve over time, especially with the strategies below.
What you eat and how you eat matter. Since GLP-1 drugs slow digestion and reduce appetite, choosing the right foods and eating habits can ease nausea, keep your blood sugar steady, and prevent stomach upset. Try these diet tips:
Bottom line: A thoughtful diet can hugely improve GLP-1 side effects. Everyone is different, so note which foods make you feel good or bad. Over time, you’ll discover the best meals that nourish you without upsetting your stomach. And remember, these adjustments are usually temporary while your body adapts.
Staying active may be the last thing on your mind if you’re feeling queasy or tired, but exercise can help alleviate many GLP-1 side effects. Physical activity helps stimulate digestion, boost energy, and improve your overall well-being. Here are some tips on exercise and daily habits:
Regular physical activity not only mitigates side effects but also enhances the benefits of GLP-1 medications. You’ll likely find that moving your body improves your mood and confidence as well. Always go at your own pace – even mild activity is better than none. Over time, as side effects fade and your strength improves, you can gradually increase intensity. The key is to keep your body gently moving and support your digestion and overall health.
Certain supplements and natural remedies – like ginger, peppermint, or fiber – can relieve GLP-1 side effects (always check with your healthcare provider before starting new supplements).
Sometimes, a few targeted supplements or home remedies can further ease your GLP-1 side effects. While you should consult with your doctor before adding anything new, many people find these helpful:
Ginger is a time-tested natural remedy for nausea and upset stomach. You can sip on ginger tea or even chew a small piece of candied ginger to help settle your stomach. Peppermint is another soothing option – a cup of peppermint tea or a peppermint oil lozenge can calm feelings of queasiness. Some studies have shown that peppermint can reduce symptoms of nausea and vomiting.
Note: If you have acid reflux, peppermint might worsen it, so ginger could be a better choice in that case. Always use herbal remedies in moderation and consult your healthcare provider, especially if you are taking other medications.
If you’re struggling to get enough fiber from food due to a smaller appetite, a fiber supplement might help keep you regular. Products like psyllium husk (Metamucil) can soften stools and ease constipation. Increase fiber intake slowly and drink plenty of water to prevent extra bloating. Your doctor or dietitian can recommend the right type and dose of fiber supplement for you. By preventing constipation, you can also reduce related nausea and discomfort.
As mentioned, staying hydrated is crucial. If you’ve had vomiting or diarrhea, you might consider an electrolyte replacement drink to replenish lost sodium and potassium. These minerals help your body retain fluid and can prevent weakness or dizziness that sometimes accompany dehydration. Even sipping on clear broth can provide electrolytes and fluid at the same time. Maintaining your electrolyte balance can also help alleviate nausea and headaches.
Some people report benefit from over-the-counter digestive enzymes or probiotics. For example, enzyme blends that include protease, lipase, and amylase may assist your stomach in digesting meals more comfortably, potentially reducing bloating and “fullness” nausea. Certain probiotic strains might improve gut motility and gas, though research is still evolving. These supplements aren’t necessary for everyone, but if you experience persistent indigestion, you may want to ask your healthcare provider if a short-term trial is appropriate.
You can also use standard remedies for symptoms if needed. For instance, antacids can help with heartburn, and medicines like simethicone (Gas-X) can relieve bloating by breaking up gas bubbles. If nausea is severe, your doctor may approve an anti-nausea medication, such as ondansetron (Zofran), in addition to the above strategies. Always follow medical advice on these. And remember, most GI side effects from GLP-1s tend to diminish over time, so you likely won’t need extra meds long-term.
Tip: Introduce only one supplement or remedy at a time, so you can tell what’s helping. Keep your healthcare team in the loop about any supplements or OTC meds you take. They can make sure there are no interactions with your prescription and that you’re using them correctly.
By focusing on wholesome diet choices, gentle physical activity, and a few supportive remedies, you can significantly reduce the side effects of GLP-1 medications. These strategies help your body adjust and make it easier to adhere to treatment in the long run.
Remember that everyone’s journey is a little different – be patient with yourself as you find what works best. Over time, your side effects should subside, especially if you continue to maintain these healthy habits. Always stay in touch with your doctor, too. With their guidance and these self-care tips, you’ll be able to enjoy the benefits of your GLP-1 medication while minimizing the bumps along the way. Here’s to feeling better and achieving your health goals with confidence!
Here’s to feeling better and achieving your health goals with confidence!
At VIVORO, we’re here to help you every step of the way, offering personalized GLP-1 programs, ongoing support, and expert care developed to make your wellness journey smoother and more sustainable.
Starting a GLP-1 therapy is not just about weight loss; it’s about feeling your best through every phase of the journey. Our goal is to help you manage side effects with the right balance of care, guidance, and lifestyle support so that you can stay consistent and confident in your progress.
Personalized GLP-1 Care Plans
Every individual responds differently to GLP-1 medications. That’s why our licensed providers design personalized treatment plans that adjust dosage, nutrition, and supplements to fit your unique needs and comfort level, helping you minimize nausea, fatigue, or digestive discomfort while maximizing results.
Expert Lifestyle Guidance
Our team goes beyond prescriptions. We guide you through practical strategies to minimize side effects by optimizing food timing, hydration, and exercise routines that complement your medication. Each recommendation is grounded in science and presented in a clear, straightforward manner to be easily applied in your daily life.
Support for Long-Term Success
At VIVORO, you’re never on your own. We offer ongoing telehealth check-ins, continuous monitoring, and holistic support to ensure your treatment stays on track. Our approach helps you stay motivated and manage side effects smoothly as your body adapts to treatment.
Your wellness journey should feel empowering, not overwhelming. With the proper guidance, you can overcome temporary side effects and focus on what matters most: lasting health, balanced energy, and confidence in your body.
Take your 5-minute assessment today and begin your journey with VIVORO.