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GLP-1/GIP + B12 Maintenance Injection

GLP-1/GIP + B12 (Tirzepatide) is a dual-action weight management medication that combines tirzepatide with vitamin B12 (cyanocobalamin). Tirzepatide works by mimicking two natural hormones in your body—GLP-1 and GIP—that help control appetite, regulate blood sugar, and promote feelings of fullness. The addition of B12 provides energy support and helps combat fatigue that can occur during weight loss. This once-weekly injection helps reduce hunger, slow digestion, and support sustainable weight loss while keeping your energy levels up throughout your journey.

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Starting at $274/Month

Dosage Options

Dosage prescribed is determined by the licensed provider based on medical judgment.

Potential Benefits

Prescription appetite suppression:
GLP-1 + B12 curbs appetite and reduces food cravings, promoting weight loss.

Scientifically backed weight loss aid:
GLP-1 + B12 is an effective weight loss aid, as demonstrated in clinical trials where some patients shed up to 15% of their body weight over 6-8 weeks.

Metabolic health booster:
GLP-1 + B12 improves metabolic health by lowering blood sugar levels, improving insulin sensitivity, and decreasing the risk of health problems that often accompany obesity such as type 2 diabetes, high blood pressure, and cardiovascular disease.

Enhanced quality of life:
GLP-1 + B12 assists in reaching a healthy weight, which can reduce symptoms like fatigue and joint pain linked to excess weight. It also improves mobility and boosts energy levels.

Order Fulfillment

A licensed provider will review within 48 hours.

Processing can take 2 – 10 business days (subject to pharmacy partners).

Once ready, shipping is via 2-day.

Disclaimer
This product is prescribed by a licensed healthcare provider based on the individual needs. These statements and the product have not been evaluated or approved by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease. Compounded medications are not FDA-approved, and their safety and efficacy have not been independently verified by the FDA. This information is provided for educational purposes only and should not be considered medical advice.

The Vivoro Experience

  • “

    Vivoro transformed my approach to wellness. The weight management program with GLP-1 therapy helped me lose 40 pounds while maintaining my busy lifestyle. The convenience and quality of care is unmatched.

  • “

    The hormone optimization program restored my energy and focus. Dr. Martinez’s personalized approach and the 24/7 support made all the difference. I feel 10 years younger.

  • “

    The sexual health program addressed issues I was too embarrassed to discuss with my regular doctor. The discreet, professional approach and effective treatments have transformed my relationship and confidence.

  • “

    I love the ongoing support and how simple the program is to follow. It truly fits my lifestyle.

Frequently Asked Questions

GLP-1/GIP + B12 is a weight management medication that combines tirzepatide with vitamin B12 (cyanocobalamin). Tirzepatide mimics two natural hormones your body makes—GLP-1 and GIP—that work together to control your appetite, keep your blood sugar steady, and make you feel full longer. The B12 is added to boost your energy and fight the tiredness that can happen when you're losing weight. This combination helps you eat less, feel satisfied, and stay energized during your weight loss journey.
This medication helps you lose weight in three main ways. First, it reduces your hunger and cravings so you naturally eat less. Second, it slows down how fast food leaves your stomach, keeping you feeling full and satisfied longer after meals. Third, it helps control your blood sugar levels, which prevents energy crashes and reduces fat storage. The added B12 keeps your energy up and supports your metabolism while you're losing weight, so you feel good throughout the process.
Vivoro partners with licensed U.S. 503A/B compounding pharmacies that prepare GLP-1 or GLP-1/GIP medicines together with:
  • B12, a vitamin
  • Glycine, an amino acid
  • A sterile liquid (such as a saline-based solution) that makes the medication ready to inject.
The exact formula and strength (mg/mL) are listed on your medication label and treatment plan.
  • GLP-1 targets the GLP-1 pathway only
  • GLP-1/GIP + targets both GLP-1 and GIP pathways
Both can help with appetite, weight, and blood sugar control. Some people do well on GLP-1 alone; others may benefit from the dual GLP-1/GIP option. Your clinician will recommend the best fit based on your health history, goals, and how you respond.
B12 (cyanocobalamin): A vitamin that provides energy, supports nerve health, and helps make healthy blood cells. When added to GLP-1, it helps fight the tiredness and low energy some people feel during weight loss. It also supports metabolism and mood.

Glycine: An amino acid (a building block of protein) that helps build muscle, supports joints and connective tissue, and improves sleep quality. When added to GLP-1, it may help preserve muscle mass during weight loss and promote better recovery and rest.

Key Difference: B12 = Energy and nerve support. Glycine = Muscle preservation and recovery. Both are common additions to GLP-1 medications, but they serve different purposes. B12 fights fatigue, while glycine helps protect your muscles as you lose weight.
Yes, both combinations are generally safe when prescribed by a licensed healthcare provider. B12 and glycine are both naturally occurring in your body. B12 is a vitamin you already get from food, and glycine is an amino acid your body makes on its own. When compounded with GLP-1 by a licensed pharmacy and used under medical supervision, these combinations have a strong safety profile. However, like any medication, they may not be right for everyone. Your provider will review your medical history to make sure it's safe for you.
Side Effects
Most side effects are mild and go away as your body adjusts. Common side effects include:
  • Nausea
  • Diarrhea or constipation
  • Stomach pain or discomfort
  • Headache
  • Fatigue
  • Decreased appetite
  • Vomiting
  • Injection site reactions (redness, swelling)
Contact your healthcare provider if side effects are severe or don't improve.
  • Wash your hands.
  • Choose an area with some fatty tissue (belly, thigh, or back of the upper arm).
  • Clean the skin with an alcohol swab and let it dry.
  • Use the syringe or device as instructed to inject the medicine just under the skin (not into a vein or muscle).
  • Rotate sites each week to avoid irritation.
    • Safely dispose of the needle in a sharps container.
  • Never share needles or medication with anyone else.
  • If you’re ever unsure, contact your care team before injecting.
Yes, you should always tell your primary care doctor about any new medications you're taking, including GLP-1. Your doctor needs to know your complete medication list to avoid drug interactions, adjust other medications if needed (like diabetes or blood pressure medications), and coordinate your overall care. Keeping your doctor informed helps ensure all your treatments work together safely.
Your exact amount depends on:
  • Your starting dose
  • Your dose-increase (titration)schedule
  • How often you inject (usually once a week)
Most patients receive a supply meant to last about one month, but your plan may be different. Your medication label and treatment plan will tell you:
  • The strength (mg/mL)
  • How much to inject each time
  • How long the vial or pen is expected to last
Protocols are personalized, but most plans include:
  • Start low, go slow – beginning at a lower dose
  • Once-weekly injections on the same day each week, unless your provider instructs differently
  • Gradual dose increases over time if tolerated and if more effect is needed
You should:
  • Follow the schedule your clinician gives you.
  • Not change your dose or skip ahead without medical guidance
  • Report side effects so your team can adjust the plan if needed
  • Your exact protocol (dose and timing) will be outlined in your Vivoro treatment plan.
GLP-1-based medicines are generally not recommended for people who:
  • Have a personal or family history of certain thyroid cancers (such as medullary thyroid carcinoma).
  • Have a rare condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
  • Have had pancreatitis in the past, unless carefully reviewed.
  • Are pregnant or planning pregnancy soon.
  • Are breastfeeding, unless approved by their doctor.
  • People with serious stomach or gut problems, severe kidney disease, or certain other health conditions may also not be good candidates.
Your Vivoro affiliated clinician will review your full reported history before prescribing.
These medications usually need refrigeration, but the exact rules depend on the pharmacy’s stability data and labeling. In general:
  • If your label says, “Keep refrigerated,” you should put it in the fridge as soon as possible after receiving it.
  • Short periods at room temperature during shipping are usually accounted for by the pharmacy.
  • If the medication has been left out longer than the label allows or was exposed to very high heat, contact the pharmacy or your care team before using it.
  • Do not guess. If you’re unsure, it’s safer to ask and possibly replace the vial than to use a dose that may not be stable or effective.